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The dangers of smoking during pregnancy are well known, but potential risks associated with smoking cessation pharmacotherapies (i.e., nicotine replacement therapy, varenicline, and bupropion) are less certain. Researchers used propensity score matching to compare rates of major congenital malformations between 326,000 infants born to mothers who smoked cigarettes but received no smoking cessation prescriptions and infants born to mothers who were prescribed nicotine replacement therapy (9000 infants), varenicline (3000), or bupropion (1000) within 90 days of conception or during the first trimester. Data were drawn from population health registries in Australia, New Zealand, Norway, and Sweden and comprised singleton live births between 20…