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Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) can occur at any age, but little is known about the presentation and prognosis of late-onset disease (after age 50). In this retrospective cohort study, Mayo Clinic investigators reviewed data from 436 patients with MOGAD and identified 107 (25%) who had been diagnosed at age ≥50. These patients were then compared with a group of 141 patients who had been diagnosed at ages 18 to 49.
The key findings:
Optic neuritis was the most common initial presentation in both groups but was more common in the late-onset group (72% vs. 58%).
One third of patients in the late-onset group were initially misdiagnosed, most often with giant-cell arteritis.
The late-onset group had more frequ…