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Most brief resolved unexplained events (BRUEs) in infants are considered higher risk, but the only management guidance available is for low-risk events (Pediatrics 2016; 137:e20160590). In this study, investigators evaluated the frequency and yield of diagnostic testing in the 90 days following a BRUE among 1042 infants at 11 Canadian hospitals (median age, 41 days). All infants were born at gestational age ≥28 weeks, and 94% of BRUEs were considered higher risk.
Key findings were as follows:
Diagnostic testing was performed in 82% of patients, yielding a causative diagnosis in 8%, incidental diagnoses in 28%, and clinically nonsignificant results in 37%.
Testing for inborn errors of metabolism and liver enzymes contributed to zero diagnoses.
R…