A Better Treatment for Children with Trichuriasis

Moxidectin–albendazole combination therapy is superior to standard albendazole monotherapy in school-aged children.

Soil-transmitted worm (helminth) infections are common in children living in tropical and subtropical low- and middle-income regions. Standard treatment with a single benzimidazole is generally effective against several common helminth infections but not trichuriasis (whipworm), which is hard to cure. Although combination therapy including moxidectin is effective against trichuriasis in adolescents and adults, it has not been evaluated in children. (Moxidectin is FDA approved for treating onchocerciasis, with a recent expansion to include children 4 years and older weighing at least 13 kg.)

To study a combination therapy with moxidectin in school-aged children with trichuriasis, investigators conducted a double-blind superiority trial in Tan…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

A Better Treatment for Children with Trichuriasis

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Reviewing Author