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A restrictive red blood cell (RBC) transfusion strategy (hemoglobin cutoff, <7 g/dL) is recommended for most hospitalized patients with anemia, including those in the intensive care unit and those with gastrointestinal bleeding. However, recent evidence, largely from the landmark MINT trial, suggests that some patients with acute myocardial infarction (MI) might benefit from a more liberal transfusion strategy — for example, with a hemoglobin cutoff <10 g/dL (NEJM JW Gen Med Dec 15 2023 and N Engl J Med 2023; 389:2446; NEJM JW Gen Med Nov 15 2024 and Ann Intern Med 2024; 177:1489). In light of this evidence, the AABB convened a multidisciplinary…