New AHA/ACC Guideline on Pulmonary Embolism

In February 2026, the American Heart Association (AHA) and American College of Cardiology (ACC) released their first-ever guideline on pulmonary embolism (PE). Created in collaboration with other professional societies, the guideline provides an evidence-based framework for evaluating and treating PE across diverse clinical settings.

Central to the guideline is a new system for clinically classifying PE — the AHA/ACC Clinical Categories (see Figure 1). Historicall…