A New Four-Drug Regimen for H. pylori Infection?

In developed countries, increasing antibiotic resistance has resulted in lower eradication rates for Helicobacter pylori. Thus, alternatives to the standard treatment regimens are badly needed. To evaluate a novel four-drug regimen, researchers at a U.S. medical center conducted an open-label, prospective, randomized trial involving 278 treatment-naive patients with H. pylori gastritis or peptic ulcer disease.

Patients received LOAD (levofloxacin, 250 mg at breakfast; omeprazole, 40 mg before breakfast; nitazoxanide 500 mg twice daily with meals; doxycycline, 100 mg at dinner) for 7 or 10 days or LAC (lansoprazole 30 mg; amoxicillin 1 g twice daily at breakfast and dinner; clarithromycin 500 mg, twice daily at breakfast and dinner) for 10 da…