New Guidelines on Treatment of Hepatitis B

Clinical Takeaway

: Highlights include recommendations for managing HBV in different phases of infection and in pregnancy.

Summarizing the American Association for the Study of Liver Diseases (AASLD)/Infectious Diseases Society of America (IDSA) Practice Guideline on Treatment of Chronic Hepatitis B

Background and Objectives

The AASLD issued treatment guidelines for hepatitis B virus (HBV) infection in 2018. The AASLD and the IDSA have now collaborated on a new guideline that focuses on several topics that required updating; readers should consult the 2018 document for the remaining unchanged information.

Key Updates

For people older than 40 or with significant liver inflammation/fibrosis (on liver biopsy/noninvasive tests) who are in the immune-tolerant phase (hepatitis B e antigen [HBeAg]-positive, HBV DNA >10,000,000 IU/mL, normal ALT), antiviral therapy is sugg…

Reviewing Author

Rajesh T. Gandhi, M.D.

Disclosures

Grant/Research SupportNIH

Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)

Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)