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Lipodermatosclerosis, also known as sclerosing panniculitis, is a chronic, painful process affecting the lower legs and believed to be caused by venous insufficiency. This condition is often associated with abnormal coagulation or deficient proteolytic process. For most authorities, optimal treatment addresses the venous insufficiency with adequate compression therapy and possibly includes low-dose oral aspirin. The use of surgical intervention or pharmacotherapy is controversial.
These authors conducted a retrospective study of 32 patients (26 women) with lipodermatosclerosis who were treated in Thailand with oral hydroxychloroquine (maximum, 6.5 mg/kg/day) and pentoxifylline (1200 mg/day) but without compression stockings. Of these patient…