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Men with nongonococcal urethritis (NGU) usually are treated empirically with azithromycin or doxycycline. However, because specific microbiological diagnoses are made rarely and microbiological proof of cure is obtained even more rarely, clinicians often have difficulty interpreting persistent or recurrent symptoms.
Researchers analyzed pre- and posttreatment urinary nucleic acid amplification test results from a prospective, randomized, nonblinded study in which azithromycin was compared with doxycycline (with or without tinidazole) in 293 heterosexual men with symptomatic NGU. Among 169 men who returned for follow-up 3 to 4 weeks after treatment, 80 exhibited persistent symptoms, and of these, 56% had no organism identified on repeat testi…