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Although virtually no data indicate an association between the measles, mumps, and rubella (MMR) vaccine and autism, speculation persists. These investigators used national registry data in Denmark to evaluate whether MMR-vaccination status was related to diagnoses of autism and other autistic-spectrum disorders (ASDs) in children born from January 1, 1991, through December 31, 1998.
Of the 537,303 children in the cohort, 440,655 (82%) received the MMR vaccine. Autism was diagnosed in 263 vaccinated children (5.9%) and 53 unvaccinated children (5.4%); ASD was diagnosed in 345 vaccinated children (7.8%) and 77 unvaccinated children (7.9%). After adjustment for potential confounders, the risks for autism and ASDs were similar in vaccinated and…