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Second-generation antihistamines (e.g., fexofenadine) cause less sedation than first-generation antihistamines (e.g., chlorpheniramine) and are similar to each other in efficacy. However, less is known about how they compare with each other in their sedating effects. These researchers provide real-life data from an ongoing British prescription-event monitoring program.
The program consists of identifying all patients who received a class of drugs and sending questionnaires to their physicians 3, 6, or 12 months after the drugs were prescribed to determine the frequency of reported side effects. In the present study, investigators obtained data on 43,363 patients who received 1 of 4 second-generation antihistamines: loratadine, cetirizine, fe…