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Normal endometrial cells found in the vaginal pool smears or endocervical aspirations of women who are postmenopausal or in their luteal phase may suggest endometrial hyperplasia and cancer. Without firm data, this association has been extended to normal endometrial cells found on Papanicolaou smears.
In this retrospective, case-control study, researchers reviewed Pap smears from 201 women diagnosed with biopsy-proven endometrial hyperplasia (103) or carcinoma (98) and compared them with Pap smears from 289 women with endometrial tissue diagnoses other than hyperplasia or carcinoma. Each woman had had at least 1 Pap smear within the 12 months before endometrial sampling and was either in the luteal phase of her menstrual cycle or postmenopau…