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Everyone is aware that nonsteroidal anti-inflammatory drugs (NSAIDs) can induce gastroduodenal ulceration, but these drugs also have been implicated in colonic ulceration. In this report, Japanese researchers described 14 patients with presumed NSAID-induced colonic ulceration diagnosed by colonoscopy at several institutions during a 3-year period. In each case, thorough evaluation ruled out other plausible causes of ulceration.
NSAIDs were used for 2 months or less in 9 of the 14 patients. Colonoscopy was performed because of rectal bleeding in 8 patients and because of anemia, abdominal pain, or diarrhea in 6. Renal failure was present in 7 patients (3 on hemodialysis). Single ulcers were found in 7 patients; multiple ulcers were found in …