Loading...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with complications in the lower gastrointestinal tract, primarily diverticular bleeding and diverticulitis (JW Gastroenterol Dec 12 2008).
Now, investigators have conducted a prospective study of the effect of NSAIDs, including aspirin, on diverticular complications in 47,210 men enrolled in the Health Professionals Follow-Up Study. Approximately 29% of participants were regular aspirin users (≥2 times per week), and 5% used NSAIDs regularly. During follow-up of 22 years, 938 incident cases of diverticulitis and 256 cases of diverticular bleeding were documented. Results were as follows:
NSAID use was associated with higher risk for diverticulitis than was aspirin use compared with …