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The September 8, 2000, Journal Watch update contained a preliminary version of the story "Ondansetron Shows Promise for Helping Control Alcoholism" (accession number 000908003). The final text of the story, in its entirety, is presented below. We apologize for any inconvenience. -- The Editors
Ondansetron Shows Promise for Helping Control Alcoholism
Serotonin receptors help mediate alcohol's effects on the brain, raising the question of whether pharmacological interventions might help control alcoholism. In this randomized, double-blind, placebo-controlled trial, researchers tested the effects of the antiemetic ondansetron, a selective serotonin-receptor antagonist, at 3 doses (1, 4, or 16 microg/kg twice daily) versus placebo in 271 alcoholi…