The Ongoing Monkeypox Outbreak Has Distinctive Features

Previously most monkeypox (MPX) cases occurred in Africa, but in recent months, an outbreak of MPX has been recognized in Europe, the U.S., and other countries outside of Africa. Now, a U.K. case series provides much-needed information about the characteristics of this outbreak.

Between May 14 and May 25, 2022, MPX was diagnosed in 54 individuals seen at four sexual health clinics in London. All identified as men who have sex with men (MSM). The following features were notable:

• 57% reported fevers.

• 94% had anogenital lesions and 56% had lymphadenopathy (mainly inguinal).

• One quarter had a concurrent sexually transmitted infection.

• Five individuals (9%) were hospitalized (four for anogenital cellulitis and one with disseminated vesicles, facial c…