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For oral antibiotic management of diverticulitis in outpatients, clinicians traditionally have used either metronidazole plus a quinolone or amoxicillin-clavulanate; no strong evidence favors one regimen over the other. Now that many experts suggest avoiding quinolones, researchers took a careful look at outcomes associated with each choice.
Analysis of two large insurance databases showed that, of 140,000 immunocompetent adults with uncomplicated diverticulitis who were treated with either regimen between 2001 and 2018, the majority (89%) received metronidazole plus a quinolone. Incidence of subsequent diverticulitis-related emergency department visits, and rates of any hospital admission, urgent surgery, or elective surgery in the next 3 y…