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Cutaneous larva migrans (CLM), an eruption associated with penetration and migration of larval hookworms, is being diagnosed with increasing frequency in the U.S. Infestations can occur domestically on salt-water beaches or can be imported after visits to areas outside of the U.S. Clinical trials have shown that oral albendazole (ALB) given as a 400-mg daily dose for 5 consecutive days, 3 days, or as a single dose has a cure rate of up to 100%. More recently, oral ivermectin (IVM) has been reported to have a 100% cure rate when given as a single oral dose (150- 200 micrograms/kg). This study from France compared the safety and efficacy of single doses of the two drugs.
Twenty-one patients with CLM were randomized to receive a single dose of …