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The natural history of large-duct primary sclerosing cholangitis (PSC) and the risk for attendant cholangiocarcinoma have been well described. However, little is known about small-duct PSC, which is defined by histologic findings of PSC, absence of cholangiographic evidence of large-duct disease, and exclusion of other chronic liver diseases.
Now, researchers have compared outcomes and long-term survival among patients with small-duct versus large-duct PSC. The study took place in Europe and the U.S. and involved extended follow-up of 83 patients with small-duct PSC and 157 with large-duct PSC, all matched by age, sex, year of diagnosis, and medical institution. The median age of the study population was 38, and both groups were 62% male.
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