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Delayed ejaculation is a side effect of antidepressant drugs; this effect can be used therapeutically for men with premature ejaculation. These two Australian studies -- both single-blind, randomized, crossover trials -- examined the selective serotonin reuptake inhibitor paroxetine as a treatment for premature ejaculation in men without depression.
The first study (26 men) compared a 20-mg dose of paroxetine, given as a single dose several hours before intercourse, with placebo. After four weeks of this "as needed" regimen, the average time from vaginal penetration to ejaculation was 3.4 minutes with paroxetine and 0.5 minutes with placebo, a significant difference. No adverse effects were reported.
The second study (42 men) compared a three…