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Although nongonococcal urethritis (NGU) is estimated to be the most common sexually transmitted disease among both men and women, we know relatively little about the microbiology of this catch-all diagnosis. Australian researchers carefully evaluated 329 men with acute urethral symptoms presenting to a single clinic during 12 months. Gonorrhea was ruled out in all cases.
Using urethral smears and first-stream urine samples, the researchers found evidence of Chlamydia trachomatis infection in 20% of cases, Mycoplasma genitalium in 9%, adenovirus in 4%, and herpes simplex virus (HSV) type 1 or 2 in 3%. Other organisms (ureaplasma species, Gardnerella vaginalis, and trichomonas) were equally or more prevalent in a control group and were not con…