Should Patients Take Once-Daily Antihypertensive Drugs in the Morning or the Evening?

In a 2019 randomized trial conducted in Spain, researchers found that taking antihypertensive medications in the evening rather than the morning significantly lowered the incidence of major adverse cardiovascular events (NEJM JW Gen Med Jan 15 2020 and Eur Heart J 2020; 41:4565). However, some experts expressed concern about the validity of that study, and in a subsequent U.K. trial, investigators failed to replicate the Spanish results (NEJM JW Gen Med Nov 15 2022 and Lancet 2022; 400:1417).

Now, Canadian investigators have published two trials — BedMed, which involved 3400 community-dwelling adults, and BedMed-Frail, which involved nearly 800 nursing home residents (many with dementia). Participants in both trials were randomized to take t…

Reviewing Authors

Jennifer L. Cluett, MD

Disclosures

Grant/Research SupportAmerican Heart Association; NIH/National Heart, Lung, and Blood Institute; NIH/National Institute on Minority Health and Health Disparities

Editorial BoardsHypertension

Leadership Positions in Professional SocietiesAmerican Heart Association (President of the Greater Boston Board of Directors)

Jennifer L. Cluett, MD

Disclosures

Grant/Research SupportAmerican Heart Association; NIH/National Heart, Lung, and Blood Institute; NIH/National Institute on Minority Health and Health Disparities

Editorial BoardsHypertension

Leadership Positions in Professional SocietiesAmerican Heart Association (President of the Greater Boston Board of Directors)

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose