Loading...
Potassium citrate is used to prevent recurrent calcium kidney stones. It works by increasing urinary pH, which enhances urinary citrate excretion; high urinary citrate concentrations increase the solubility of stone-forming salts. To assess the value of potassium citrate therapy, researchers at Duke University’s Comprehensive Kidney Stone Center conducted a retrospective cohort study of 503 patients who experienced recurrent kidney stones and who received potassium citrate therapy. Most patients had some combination of hypocitraturia, low urine volume, hypercalciuria, and gout.
On 24-hour urinary metabolic profiles at baseline and after at least 6 months of potassium citrate therapy, mean urinary citrate levels rose from 470 to 700 mg, and m…