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Patients with chronic pancreatitis often have abdominal pain, which can be intractable and difficult to control. Therapeutic options are limited, and many patients become dependent on, and even addicted to, narcotic analgesics for pain control. Nonopioid agents have been suggested as adjuncts to narcotics but have not been tested in randomized studies. These include gabapentoids (gabapentin and pregabalin), which have shown efficacy in treating a wide variety of neuropathic conditions that seem to share neuropathic mechanisms and central pain processing patterns found in painful chronic pancreatitis.
To investigate the efficacy and safety of the gabapentoid pregabalin in reducing pain from chronic pancreatitis, researchers in Denmark and the…