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Vaccines against human papillomavirus (HPV) are administered largely to women of reproductive age. If these vaccines were to cause adverse pregnancy outcomes, of which miscarriage is the most common, then the benefit (i.e., prevention of cervical cancer) would need to be weighed against those risks. To determine whether the HPV vaccine Cervarix raises risk for miscarriage, international investigators examined data from two randomized controlled trials of this vaccine — one was funded by the manufacturer. Cervarix is prepared using a new adjuvant, and little information is available about the adjuvant's safety in pregnant women.
More than 26,000 women received three doses of HPV-16/18 vaccine or hepatitis A vaccine (control group) during a 6-…