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Immunoglobulin A (IgA) antibodies, such as anti-tissue transglutaminase and anti-endomysial antibodies, are used to screen for and diagnose celiac disease. Approximately 2% to 3% of the general population is deficient in total serum IgA; therefore, when screening for celiac disease, it is common to measure both anti-tissue transglutaminase IgA as well as total serum IgA. Patients deficient in total serum IgA can be screened for celiac disease using immunoglobulin G (IgG) antibodies.
To characterize clinical features of celiac disease in patients with IgA deficiency, investigators conducted a single-center, retrospective cohort study of 1815 patients with celiac disease. Patients with IgA deficiency were more likely than those with normal IgA…