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Both prochlorperazine (Compazine and generics) and promethazine (Phenergan and generics) are prescribed frequently in emergency departments (EDs) for nausea and vomiting. In this randomized double-blind trial, researchers compared the 2 drugs in 84 adults who presented to the ED with nausea and vomiting from uncomplicated gastritis or gastroenteritis. Patients were enrolled only if they were unable to drink fluids and if they required intravenous hydration.
Patients received either prochlorperazine (10 mg) or promethazine (25 mg) intravenously. Patients rated their nausea on a visual analog scale just before receiving medication and at 30 and 60 minutes after medication had been given. The decrease in the median nausea score was significantl…