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Most clinicians believe that combination estrogen–progestin oral contraceptives are associated with substantial excess risk for venous thromboembolism (VTE) and that progestin-only contraceptives are less likely to impart risk for VTE. To study the association between progestin-only contraception and VTE risk, investigators in Sweden compared 7597 reproductive-aged women with incident VTE and 37,985 matched controls without VTE; about one quarter of cases and controls had progestin-only contraception exposure. The investigators divided progestin-only contraceptives into four groups:
High-dose progestin (i.e., depot medroxyprogesterone acetate [DMPA])
Intermediate-dose progestin (i.e., etonogestrel implant or levonorgestrel implant)
Low-…