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Occasionally we resort to prophylactic therapy for women with recurrent urinary tract infections (UTIs). This randomized study examined outcomes with ciprofloxacin prophylaxis in 135 sexually active premenopausal women with at least three documented lower UTIs in the preceding 12 months. One group received a daily 125 mg dose of ciprofloxacin, while the other group took the drug only after intercourse (on average, twice a week).
The two regimens were equally effective during one year of prophylaxis: only two women from each group had a symptomatic UTI. Two isolates from the patients with UTIs were resistant to ciprofloxacin. During the next 12 months (after prophylaxis was discontinued), the incidence of UTI climbed to 0.44 episodes per pati…