Pseudocatalase and Vitiligo

Two thirds of children treated with pseudocatalase PC-KUS achieved 75% improvement or better in their vitiligo.

Hydrogen peroxide–mediated lipid peroxidation may damage epidermal cells, causing vitiligo. In cultured melanocytes and keratinocytes, vacuolization caused by peroxidation can be prevented by catalase, which breaks down peroxides, and by “pseudocatalase” (PC-KUS), a complex of bis-Mn^III [EDTA]₂ [HCO₃^-]₂, which can be applied to skin and activated by narrow-band ultraviolet-B (NB-UVB) radiation.

In this study, 71 children with vitiligo were treated with PC-KUS that was activated by UVB daily. The PC-KUS topical preparation was applied twice daily to the entire body. NB-UVB was administered once daily for 14 days and then twice weekly for 4 weeks. Thereafter, PC-KUS was applied once daily, and up to 1 hour of sun exposure daily was allowed. Te…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)