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Uncontrolled studies dating back to the 1940s, and a small controlled trial published in 1991, have suggested that pyridoxine reduces nausea and vomiting in pregnancy. This large double-blind study from Thailand randomized 342 pregnant women with nausea (gestational age less than 18 weeks) to receive either pyridoxine hydrochloride (10 mg three times a day for five days) or placebo. The women graded the severity of nausea on a visual analog scale from 0 (no nausea) to 10 (maximum nausea). They also recorded the number of vomiting episodes that occurred 24 hours prior to treatment and on each day of treatment. On each of the five study days, the mean improvement in nausea scores was significantly greater with pyridoxine than with placebo. Th…