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Primary hyperparathyroidism may cause or worsen various health issues. While parathyroidectomy has been shown to improve certain outcomes such as bone and kidney-related disorders, data on other outcomes are unclear. Two recent studies (one based in the United States, the other in Israel) addressed this gap.
In both studies, researchers used large national databases to identify adult patients with primary hyperparathyroidism and matched those who underwent parathyroidectomy with others who received medical management alone (see ). The U.S.-based study examined new-onset mental health disorders among 37,000 patients; 1:1 matching accounted for many comorbidities and medications including antidepressants and anxiolytics. The Isr…