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Kawasaki disease (KD), one of the most common types of pediatric vasculitis, is typically self-limited but can cause coronary artery aneurysms that lead to complications in adulthood. High-dose aspirin (80–100 mg/kg/day) has historically been used to prevent these aneurysms, but a growing body of evidence suggests that it has no benefit.
Given this shifting evidence, some hospitals have changed their KD treatment protocols to include low-dose aspirin (3–5 mg/kg/day) instead of high-dose aspirin. Now, researchers describe outcomes from one such hospital. The study involved 300 children who received high-dose aspirin prior to the protocol change and 200 who received low-dose aspirin after the change; all received intravenous immunoglobu…