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Guillain-Barré syndrome (GBS) is a heterogeneous group of disorders that typically present as rapidly progressive weakness, often accompanied by sensory symptoms, along with facial, bulbar, and respiratory compromise. GBS is usually a monophasic illness; however, an estimated 5% of patients have recurrent attacks. In this retrospective case-control study, investigators compared findings in 32 patients with recurrent GBS with findings in 476 patients with nonrecurrent GBS.
Compared with the nonrecurrent-GBS group, the recurrent-GBS group was younger (mean age, 34.2 vs. 46.9 years; 44% were <30 years vs. 22% of the nonrecurrent group), had milder symptoms, and was more likely to have the Miller Fisher syndrome variant during the first attack. …