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Fluconazole is used to treat deep fungal infections such as blastomycosis, sporotrichosis, histoplasmosis, cryptococcosis, coccidioidomycosis, and candidiasis. Therapy may be associated with gastrointestinal upset or rash, but serious problems are rare. The Mycoses Study Group describes 33 patients who developed alopecia while taking fluconazole.
Alopecia, decribed as "substantial" hair loss, occurred on the scalp in all patients and at other sites in about one third. Patients ranged from 26 to 66 years in age; one third had AIDS, and 45% were female. Most patients (88%) received at least 400 mg of fluconazole daily for a mean of seven months. Alopecia was first noted about three months after starting therapy (as early as two weeks in one ca…