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Preeclampsia complicates about 3% of pregnancies. Since there is a significant reoccurrence rate and clustering within families, there may be a genetic component from maternal genes as well as from paternal genes present in the fetus. These Norwegian authors used national data bases to determine inheritance patterns in 363,758 pairs of pregnancies with the same mother and father, 14,266 pairs in which the mother was the same but the fathers were different, and 26,152 pairs in which the father was the same but the mothers were different.
Parity affected risk for preeclampsia; second pregnancies had a lower risk of preeclampsia than first (1.7% vs. 3.0%) if the parents were the same, but the risk increased to 1.9% if the father was different (…