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An estimated 6% of pregnant women receive prescription topical corticosteroids (TCS), which are pregnancy risk category C. Animal studies show teratogenic effects, but data are limited and conflicting regarding use in pregnant women. Investigators performed a retrospective cohort study using data from the U.K. National Health Service. They documented type and dosages of TCS prescriptions filled at pharmacies by 2658 pregnant women over a 7-year period, who were matched with 7246 unexposed pregnant controls. Mean dispensed quantity of potent or very potent topical steroids during the whole pregnancy was 64 grams (range, 15–490). Women who received corticosteroids via other routes during pregnancy and those with multiple pregnancy or assisted…