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When cancer is diagnosed during pregnancy, women, obstetricians, and oncologists must make difficult therapeutic decisions based on limited data. To determine long-term outcomes after prenatal exposure to chemotherapy, investigators assessed neurologic, cardiac, and behavioral outcomes in 70 children in three European countries who were exposed in utero to cytotoxic drugs for cancer treatment. Children were assessed periodically between age 18 months and 18 years.
During pregnancy, half of the women received chemotherapy only and half also underwent surgery, radiation therapy, or all three treatment modalities. Breast cancer was the most common type of malignancy, and anthracyclines were the most commonly used chemotherapeutic agents. Median…