Selective Serotonin Reuptake Inhibitors

Either psychotherapy or antidepressant medication is effective treatment for mild-to-moderate depression, and combining the two is optimal therapy for moderate-to-severe depression. This article will provide an overview of one class of antidepressants: selective serotonin reuptake inhibitors (SSRIs). In addition to treating depression, some SSRIs are FDA-approved to treat obsessive-compulsive disorder, bulimia nervosa, panic disorder, social phobia, post-traumatic stress disorder, and premenstrual dysmorphic disorder -- each of which frequently coexists with depression. All SSRIs can be taken once daily, are quite benign in overdose, and are equally efficacious. Overall, choices among SSRIs are based on access, cost, convenience, and side e…