Loading...
Premature ejaculation is one of the most common sexual complaints, affecting up to 30% of men. Both animal and human studies suggest that serotonin plays a primary role in controlling ejaculation. This randomized placebo-controlled study examined the effect of the selective serotonin reuptake inhibitor (SSRI) sertraline for treating premature ejaculation.
Researchers randomized 52 heterosexual males with steady partners and self-described premature ejaculation to receive either sertraline (50 to 200 mg) or placebo for eight weeks. Patients with scores of 14 or more on the Hamilton Depression Scale (Ham-D) were excluded. Patient diaries and patient and partner interviews were used to monitor latency to ejaculation, number of episodes of prema…