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Because delayed ejaculation is one side effect of selective serotonin reuptake inhibitors (SSRIs), they are sometimes used off-label to treat premature ejaculation. However, long-acting SSRIs require chronic dosing, which can cause other side effects, including decreased libido and erectile dysfunction. Dapoxetine is a short-acting SSRI (time to peak concentration, 1 hour) developed specifically for on-demand treatment of premature ejaculation.
In two 12-week manufacturer-sponsored randomized trials, 2600 men (mean age, 40; 87% white) with self-reported moderate-to-severe premature ejaculation (average duration, 16 years) took dapoxetine (30 mg or 60 mg) or placebo 1 to 3 hours before anticipated sexual intercourse. All subjects had steady f…