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Radiotherapy is a key treatment component for a variety of cancers.
Innovations in imaging and in delivery of radiation have improved the accuracy and precision of radiation treatments, leading to marked reductions in the incidence and severity of effects on normal tissues.
The expected side effects (see ) from radiation treatments depend on the dose delivered, the volume of tissue treated, concurrent treatments (e.g., surgery and systemic therapy), and coexisting conditions. Our understanding of biologic processes in normal tissue after radiation exposure has deepened in recent years, and several candidate agents have been developed for prevention, mitigation, and treatment of side effects of irradiation.
Management of radi…