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Penicillin and tetracycline are no longer recommended as first-line treatments for uncomplicated gonorrhea because of the increasing incidence of drug-resistant organisms. Instead, intramuscular injections of ceftriaxone are the treatment of choice. This study compares IM ceftriaxone with a new oral cephalosporin, cefixime.
The multicenter trial randomly allocated 333 patients with uncomplicated gonorrhea to receive single doses of 400 mg or 800 mg of oral cefixime or 250 mg of IM ceftriaxone. Initial and follow-up evaluations were extensive. Complete cure was achieved in 96 percent, 98 percent, and 98 percent of the three treatment groups, respectively. Mild gastrointestinal side effects occurred slightly more often in the group taking 800 …