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Circadian rhythms are important for homeostasis of chondrocytes and articular cartilage, suggesting that poor sleep could heighten risk for osteoarthritis (OA). Researchers used U.K. Biobank data to examine associations between patient-reported sleep disturbances and subsequent lower-extremity OA, adjusted by age, gender, body-mass index, and frequency of physical labor.
The shortest sleep duration (<6 hours per night) was associated with the highest risk for osteoarthritis: Compared with 7 hours per night, risk for a diagnosis of knee or hip OA was ≈30% higher and for knee or hip arthroplasty, ≈20% higher.
Self-reported poor-quality sleep was associated with similarly elevated risks for OA diagnosis and arthroplasty.
Night-s…