SOFA-2: A Revised Organ Failure Score

Structured measures of vital organ function, such as the APACHE, MODS, and Sequential Organ Failure Assessment (SOFA) scores, help quantify illness severity in critically ill patients. Clinicians encounter their use in clinical prediction tools like Sepsis-3 — which includes the SOFA score and its simplified version, qSOFA — and use them in estimating outcomes during conversations with patients and their families. Now, after 3 decades of advances in critical care, a 60-member international task force has revised the SOFA score (now renamed SOFA-1) and provided us with the SOFA-2 score after multiple rounds of expert discussion, systematic reviews, artificial intelligence computations, and analysis of more than 3.3 million intensive c…