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Among adults with pulmonary arterial hypertension who had received the diagnosis less than 1 year earlier, the addition of sotatercept to background therapy resulted in a lower risk of clinical worsening than placebo.
McLaughlin VV, et al. Sotatercept for pulmonary arterial hypertension within the first year after diagnosis. N Engl J Med 2025 Oct 23; 393:1599. DOI: 10.1056/NEJMoa2508170.