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Bacterial vaginosis (BV) is notoriously difficult to cure, with a relapse rate exceeding 50% in the first few months after treatment. Although BV has many of the hallmarks of a sexually transmitted infection, trials of oral metronidazole to treat sexual partners of patients with BV have not demonstrated an improvement in the cure rate.
In an open-label trial, Australian researchers randomized 164 premenopausal women with BV and their male partners to either treatment of the woman only or to treatment of both partners within 1 week of each other. Most women had at least one prior BV episode. Ninety percent of women received oral metronidazole, and 10% received intravaginal clindamycin or metronidazole. Men received 1 week of both oral metroni…