Loading...
Several studies have demonstrated that both sulfasalazine and prednisone are effective treatments for Crohn's disease, although some disagreement remains about the relative benefits of these drugs for disease in different locations (colon vs. small bowel). In addition, previous studies have not specifically addressed the additive benefits of these drugs. In this 16-week trial, 60 patients with new-onset or relapsing Crohn's disease were randomly assigned to receive sulfasalazine (4 to 6 g/day) plus either placebo or prednisone (30 mg/day initially, tapered within 8 weeks to a maintenance dosage of 10 mg/day).
During the first 6 weeks, the group receiving combined therapy had a significantly better response than the group receiving sulfasalaz…