Survival of Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrosis

Earlier, extent of detached skin, and later, comorbidity are significant predictors of prognosis.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe reactions, mostly to drugs. Mortality associated with these conditions has been documented in many prior studies. These authors analyzed data from the RegiSCAR ((International Registry of Severe Cutaneous Adverse Reactions to drugs) database, where related data have been collected since 2003, to assess risk factors for mortality for SJS and TEN. Most of the included patients were from Germany or France (85%), with the remainder from other European countries (Austria, Italy, and the Netherlands) and Israel.

Mortality rates were 23% at 6 weeks and 34% at 1 year. Short-term and long-term analyses of mortality revealed different relevant factors. In the first 90 days,…

Reviewing Author

Jeffrey P. Callen, MD

Disclosures

Consultant / Advisory board XOMA; Eli Lilly; Celgene

Equity Various trust accounts

Editorial boards JAMA Dermatology; UpToDate

Leadership positions in professional societies Association of Professors of Dermatology (President-Elect)